Tetracycline antibiotics and resistance

TH Grossman - Cold Spring Harbor perspectives …, 2016 - perspectivesinmedicine.cshlp.org
Tetracyclines possess many properties considered ideal for antibiotic drugs, including
activity against Gram-positive and-negative pathogens, proven clinical safety, acceptable …

The impact of insertion sequences on bacterial genome plasticity and adaptability

J Vandecraen, M Chandler, A Aertsen… - Critical reviews in …, 2017 - Taylor & Francis
Transposable elements (TE), small mobile genetic elements unable to exist independently
of the host genome, were initially believed to be exclusively deleterious genomic parasites …

cis-Antisense RNA, Another Level of Gene Regulation in Bacteria

J Georg, WR Hess - Microbiology and Molecular Biology Reviews, 2011 - Am Soc Microbiol
SUMMARY A substantial amount of antisense transcription is a hallmark of gene expression
in eukaryotes. However, antisense transcription was first demonstrated in bacteria almost 50 …

The IS6 family, a clinically important group of insertion sequences including IS26

A Varani, S He, P Siguier, K Ross, M Chandler - Mobile Dna, 2021 - Springer
The IS 6 family of bacterial and archaeal insertion sequences, first identified in the early
1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic …

Everyman's guide to bacterial insertion sequences

P Siguier, E Gourbeyre, A Varani, B Ton-Hoang… - Mobile DNA …, 2015 - Wiley Online Library
We have divided this review into two major sections. In one, we have attempted to present
an overview of our current understanding of prokaryotic insertion sequences (IS), their …

The Birth and Demise of the ISApl1-mcr-1-ISApl1 Composite Transposon: the Vehicle for Transferable Colistin Resistance

E Snesrud, P McGann, M Chandler - MBio, 2018 - Am Soc Microbiol
The origin and mobilization of the~ 2,609-bp DNA segment containing the mobile colistin
resistance gene mcr-1 continue to be sources of uncertainty, but recent evidence suggests …

Causes of insertion sequences abundance in prokaryotic genomes

M Touchon, EPC Rocha - Molecular biology and evolution, 2007 - academic.oup.com
Insertion sequences (ISs) are the smallest and most frequent transposable elements in
prokaryotes where they play an important evolutionary role by promoting gene inactivation …

Deep sequencing analysis of the Methanosarcina mazei Gö1 transcriptome in response to nitrogen availability

D Jäger, CM Sharma, J Thomsen… - Proceedings of the …, 2009 - National Acad Sciences
Methanosarcina mazei and related mesophilic archaea are the only organisms fermenting
acetate, methylamines, and methanol to methane and carbon dioxide, contributing …

In Vitro Analysis of ISEcp1B-Mediated Mobilization of Naturally Occurring β-Lactamase Gene blaCTX-M of Kluyvera ascorbata

MF Lartigue, L Poirel, D Aubert… - Antimicrobial agents and …, 2006 - Am Soc Microbiol
ABSTRACT IS Ecp1B has been reported to be associated with and to mobilize the emerging
expanded-spectrum β-lactamase bla CTX-M genes in Enterobacteriaceae. Thus, the ability …

The origin of RNA interference: Adaptive or neutral evolution?

A Torri, J Jaeger, T Pradeu, MC Saleh - PLoS Biology, 2022 - journals.plos.org
The origin of RNA interference (RNAi) is usually explained by a defense-based hypothesis,
in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses …