Prevalence of peripheral neuropathy in pre-diabetes: a systematic review

V Kirthi, A Perumbalath, E Brown, S Nevitt… - BMJ Open Diabetes …, 2021 - drc.bmj.com
There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to
determine its prevalence, including the impact of diagnostic methodology on prevalence …

Prevention and management strategies for diabetic neuropathy

S Smith, P Normahani, T Lane… - Life, 2022 - mdpi.com
Diabetic neuropathy (DN) is a common complication of diabetes that is becoming an
increasing concern as the prevalence of diabetes rapidly rises. There are several types of …

Epigenetic mechanisms in type 2 diabetes retinopathy: a systematic review

A Milluzzo, A Maugeri, M Barchitta, L Sciacca… - International journal of …, 2021 - mdpi.com
Diabetic retinopathy (DR) is one of the main causes of vision loss in middle-aged
economically active people. Modifiable (ie, hyperglycaemia, hypertension, hyperlipidaemia …

The prevalence of retinopathy in prediabetes: a systematic review

V Kirthi, P Nderitu, U Alam, JR Evans, S Nevitt… - Survey of …, 2022 - Elsevier
Diabetic retinopathy is a leading cause of vision loss globally. The current diagnostic
thresholds for diabetes are still based on historic data correlating glycemic parameters with …

Metformin and retinal diseases in preclinical and clinical studies: Insights and review of literature

SV Amin, S Khanna, SP Parvar… - Experimental …, 2022 - journals.sagepub.com
Metformin is one of the most prescribed drugs in the world giving potential health benefits
beyond that of type 2 diabetes (T2DM). Emerging evidence suggests that it may have …

Chronic microvascular complications in prediabetic states—An overview

A Baranowska-Jurkun, W Matuszewski… - Journal of Clinical …, 2020 - mdpi.com
A prediabetic state is a major risk factor for the development of diabetes, and, because of an
identical pathophysiological background of both conditions, their prevalence increases …

Dietary flavonoids prevent diabetes through epigenetic regulation: advance and challenge

S Han, Y Luo, B Liu, T Guo, D Qin… - Critical Reviews in Food …, 2023 - Taylor & Francis
The pathophysiology of diabetes has been studied extensively in various countries, but
effective prevention and treatment methods are still insufficient. In recent years, epigenetics …

In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D3, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K …

RA Almaimani, A Aslam, J Ahmad, MZ El-Readi… - Cancers, 2022 - mdpi.com
Simple Summary Failure of chemotherapy is common during the treatment of colon cancer,
and there is a compelling need to develop alternative therapeutic approaches against this …

Effects of medications on hypoxia‐inducible factor in the retina: A review

AH Kim, M Kolesnikova, WK Ngo… - Clinical & experimental …, 2023 - Wiley Online Library
Hypoxia‐inducible factor (HIF) plays a critical role in the mechanisms that allow cells to
adapt to various oxygen levels in the environment. Specifically, HIF‐1⍺ has shown to be …

Skeletal muscle microvascular dysfunction in obesity-related insulin resistance: pathophysiological mechanisms and therapeutic perspectives

CK Ugwoke, E Cvetko, N Umek - International journal of molecular …, 2022 - mdpi.com
Obesity is a worrisomely escalating public health problem globally and one of the leading
causes of morbidity and mortality from noncommunicable disease. The epidemiological link …