In this issue of Structure, Holmes et al.(2005) describe elements of an innate defense
mechanism that provides mammals a means to restrict bacterial growth. The host protein …

OBJECTIVE: Schizophrenia is associated with several chronic physical illnesses and a
shorter life expectancy, compared with life expectancy in the general population. One …

BackgroundThe increased prevalence of diabetes in schizophrenia is partly attributed to
antipsychotic treatment, in particular second-generation antipsychotics, but the evidence has …

Adverse metabolic effects, such as diabetes mellitus, lipid abnormalities and weight gain,
have increasingly been recognised with the use of the newer, so-called atypical …

Objective: To determine the prevalence, trends, and factors associated with antipsychotic
polypharmacy categorized according to type of antipsychotic and duration of use and to …

Close to 19 million US adults have severe mental illnesses (SMI), and they die, on average,
25 years earlier than the general population, most often from cardiovascular disease (CVD) …

Abstract Treatment with second-generation antipsychotics (SGAs) has been associated with
weight gain and the development of diabetes mellitus, although the mechanisms are …

Atypical antipsychotics are a major advance in the management of schizophrenia. The
reevaluation of widely held risk/benefit assessments of the various atypical antipsychotics …

The physical health of patients with schizophrenia remains a concern. Yet the quality of
medical and psychiatric care of patients with comorbid physical and mental health disorders …

The most frequent hyperglycemic emergency and the leading cause of death in people with
diabetes mellitus is diabetic ketoacidosis (DKA). DKA is common in people with type 1 …