Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates

HM Abdelaziz, M Gaber, MM Abd-Elwakil… - Journal of Controlled …, 2018 - Elsevier
There is progressive evolution in the use of inhalable drug delivery systems (DDSs) for lung
cancer therapy. The inhalation route offers many advantages, being non-invasive method of …

The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

[HTML][HTML] Insight into the prospects for RNAi therapy of cancer

Z Tian, G Liang, K Cui, Y Liang, Q Wang, S Lv… - Frontiers in …, 2021 - frontiersin.org
RNA interference (RNAi), also known as gene silencing, is a biological process that
prevents gene expression in certain diseases such as cancer. It can be used to improve the …

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

YY Jhan, D Prasca-Chamorro, GP Zuniga… - International journal of …, 2020 - Elsevier
The low yield of extracellular vesicle (EV) secretion is a major obstacle for mass production
and limits their potential for clinical applications as a drug delivery platform. Here, we mass …

Gold nanoparticles in microelectronics advancements and biomedical applications

MM Ghobashy, SA Alkhursani, HA Alqahtani… - Materials Science and …, 2024 - Elsevier
Gold nanoparticles (AuNPs) possess unique size-dependent optical, electronic, and
chemical properties, making them auspicious and tunable nanoscale building blocks for …

Induction of virus resistance by exogenous application of double-stranded RNA

N Mitter, EA Worrall, KE Robinson, ZP Xu… - Current opinion in …, 2017 - Elsevier
Highlights•Exogenous application of dsRNA can induce antiviral silencing in plants.•Naked
dsRNA on leaves affords virus protection only up to 5 days postspray.•Nanoparticle …

Nanoparticles for local delivery of siRNA in lung therapy

M Kubczak, S Michlewska, M Bryszewska… - Advanced Drug Delivery …, 2021 - Elsevier
An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide
delivery into the lung is presented in this review, with a special focus on lung cancer. Due to …

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

KS Allemailem, MA Alsahli, A Almatroudi… - Cancer …, 2022 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats‐associated protein
(CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust …

[HTML][HTML] Potential applications of nanoparticles in improving the outcome of lung cancer treatment

A Girigoswami, K Girigoswami - Genes, 2023 - mdpi.com
Lung cancer is managed using conventional therapies, including chemotherapy, radiation
therapy, or a combination of both. Each of these therapies has its own limitations, such as …

[HTML][HTML] The nanopharmacology and nanotoxicology of nanomaterials: new opportunities and challenges

A Radomska, J Leszczyszyn… - Advances in Clinical …, 2016 - advances.umw.edu.pl
The very dynamic growth of nanotechnology, nanomaterials (sized 1–100 nm) and their
medical applications over the past 10 years has promised to add a new impetus to the …