Targeted genome editing has become a powerful genetic tool for studying gene function or
for modifying genomes by correcting defective genes or introducing genes. A variety of …

One of the fundamental discoveries in the field of biology is the ability to modulate the
genome and to monitor the functional outputs derived from genomic alterations. In order to …

Cancer is a significant challenge for effective treatment due to its complex mechanism,
different progressing stages, and lack of adequate procedures for screening and …

In vivo genome editing represents an emerging field in the treatment of monogenic
disorders, as it may constitute a solution to the current hurdles in classic gene addition …

Introduction: Glioblastoma (GBM) is a highly aggressive brain tumor and is one of the most
lethal human cancers. Chimeric antigen receptor (CAR) T cell therapy has markedly …

The CRISPR-associated Cas9 system can modulate disease-causing alleles both in vivo
and ex vivo, raising the possibility of therapeutic genome editing. In addition to gene …

Gene targeting constitutes a new step in the development of gene therapy for inherited
diseases. Although previous studies have shown the feasibility of editing fibroblasts from …

Simple Summary Pancreatic cancer is one of the most lethal cancers. Although complete
surgical resection is the only curative treatment for pancreatic cancer, a late diagnosis is …

Быстро развивающиеся технологии редактирования генома из научно-
исследовательских лабораторий уверенно переходят в клиническую практику …

In past two decades the gene therapy using genetic modified autologous hematopoietic
stem cells (HSCs) transduced with the viral vector has become a promising alternative …