Sequencing and characterizing short tandem repeats in the human genome
HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species
M Verbiest, M Maksimov, Y Jin… - Journal of …, 2023 - academic.oup.com
Short tandem repeats (STRs) are units of 1–6 bp that repeat in a tandem fashion in DNA.
Along with single nucleotide polymorphisms and large structural variations, they are among …
Along with single nucleotide polymorphisms and large structural variations, they are among …
Dissection of a rapidly evolving wheat resistance gene cluster by long-read genome sequencing accelerated the cloning of Pm69
Gene cloning in repeat-rich polyploid genomes remains challenging. Here, we describe a
strategy for overcoming major bottlenecks in cloning of the powdery mildew resistance gene …
strategy for overcoming major bottlenecks in cloning of the powdery mildew resistance gene …
The enormous repetitive Antarctic krill genome reveals environmental adaptations and population insights
Antarctic krill (Euphausia superba) is Earth's most abundant wild animal, and its enormous
biomass is vital to the Southern Ocean ecosystem. Here, we report a 48.01-Gb chromosome …
biomass is vital to the Southern Ocean ecosystem. Here, we report a 48.01-Gb chromosome …
Bacterial NLR-related proteins protect against phage
EM Kibby, AN Conte, AM Burroughs, TA Nagy… - Cell, 2023 - cell.com
Bacteria use a wide range of immune pathways to counter phage infection. A subset of these
genes shares homology with components of eukaryotic immune systems, suggesting that …
genes shares homology with components of eukaryotic immune systems, suggesting that …
Spliceator: multi-species splice site prediction using convolutional neural networks
Background Ab initio prediction of splice sites is an essential step in eukaryotic genome
annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene …
annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene …
HiFi metagenomic sequencing enables assembly of accurate and complete genomes from human gut microbiota
Advances in metagenomic assembly have led to the discovery of genomes belonging to
uncultured microorganisms. Metagenome-assembled genomes (MAGs) often suffer from …
uncultured microorganisms. Metagenome-assembled genomes (MAGs) often suffer from …
SemiBin2: self-supervised contrastive learning leads to better MAGs for short-and long-read sequencing
Motivation Metagenomic binning methods to reconstruct metagenome-assembled genomes
(MAGs) from environmental samples have been widely used in large-scale metagenomic …
(MAGs) from environmental samples have been widely used in large-scale metagenomic …
The versatile Pseudomonas aeruginosa biofilm matrix protein CdrA promotes aggregation through different extracellular exopolysaccharide interactions
C Reichhardt, HM Jacobs, M Matwichuk… - Journal of …, 2020 - Am Soc Microbiol
Pseudomonas aeruginosa is an important pathogen that causes chronic infections that
involve multicellular aggregates called biofilms. Within biofilms, bacteria are surrounded in a …
involve multicellular aggregates called biofilms. Within biofilms, bacteria are surrounded in a …
The haplotype-resolved chromosome pairs of a heterozygous diploid African cassava cultivar reveal novel pan-genome and allele-specific transcriptome features
W Qi, YW Lim, A Patrignani, P Schläpfer… - …, 2022 - academic.oup.com
Abstract Background Cassava (Manihot esculenta) is an important clonally propagated food
crop in tropical and subtropical regions worldwide. Genetic gain by molecular breeding has …
crop in tropical and subtropical regions worldwide. Genetic gain by molecular breeding has …