Abstract Purpose of Review Since it first appeared, multisystem inflammatory syndrome in
children (MIS-C) associated with coronavirus disease 2019 (COVID-19) has been compared …

Since the arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in
December 2019, its characterization as a novel human pathogen, and the resulting …

Abstract The type I IFN (IFN‐I) system is essential to limit severe viral disease in humans.
Thus, IFN‐I deficiencies are associated with serious life‐threatening infections. Remarkably …

Multisystem inflammatory syndrome in children (MIS‐C) is a rare, but severe complication of
coronavirus disease 2019 (COVID‐19). It develops approximately 4 weeks after severe …

Autoantibodies (AABs) neutralizing type I interferons (IFN) underlie about 15% of cases of
critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity …

Background Autoantibodies against type I IFNs occur in approximately 10% of adults with
life-threatening coronavirus disease 2019 (COVID-19). The frequency of anti-IFN …

Infectious susceptibility is a component of many inborn errors of immunity. Nevertheless,
antibiotic use is often used as a surrogate in history taking for infectious susceptibility …

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …

Introduction Despite the existing data on the Multisystem Inflammatory Syndrome in Children
(MIS-C), the factors that determine these patients evolution remain elusive. Answers may lie …

Data regarding response to SARS-CoV-2 immunization in pediatric patients with
predominantly antibody deficiency (PAD) is limited. We evaluated SARS-CoV-2 …