Epileptic activity in Alzheimer's disease: causes and clinical relevance
KA Vossel, MC Tartaglia, HB Nygaard… - The Lancet …, 2017 - thelancet.com
Epileptic activity is frequently associated with Alzheimer's disease; this association has
therapeutic implications, because epileptic activity can occur at early disease stages and …
therapeutic implications, because epileptic activity can occur at early disease stages and …
Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease
S Hijazi, AB Smit, RE van Kesteren - Molecular Psychiatry, 2023 - nature.com
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …
morphological and functional properties that allow them to precisely control local circuitry …
[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease
J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …
system in age-related episodic memory impairments in humans, with a particular focus on …
GABAergic inhibitory interneuron deficits in Alzheimer's disease: implications for treatment
Y Xu, M Zhao, Y Han, H Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease
S Hijazi, TS Heistek, P Scheltens, U Neumann… - Molecular …, 2020 - nature.com
Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …
Behavioural and psychological symptoms of dementia in mouse models of Alzheimer's disease-related pathology
F Kosel, JMS Pelley, TB Franklin - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …
The link between Alzheimer disease and metabolic syndrome: a mutual relationship and long rigorous investigation
HM Al-Kuraishy, MS Jabir, AK Albuhadily… - Ageing Research …, 2023 - Elsevier
It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …
Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease
Preclinical and clinical data support the use of focused ultrasound (FUS), in the presence of
intravenously injected microbubbles, to safely and transiently increase the permeability of …
intravenously injected microbubbles, to safely and transiently increase the permeability of …
Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance
EV Varela, G Etter, S Williams - Neurobiology of disease, 2019 - Elsevier
The interplay between excitatory and inhibitory circuits underlies the brain's processes and
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …
Insights on benzodiazepines' potential in Alzheimer's disease
Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …