The research on 1, 2, 3-triazoles has been lively and ever-growing since its stimulation by
the advent of click chemistry. The attractiveness of 1H-1, 2, 3-triazoles and their derivatives …

Mild, efficient, copper‐catalyzed N‐arylation procedures for nitrogen heterocycles, amides,
carbamates, and C‐arylation procedures for malonic acid derivatives have been developed …

The ion chemistry of helium currently embraces a large variety of species, mostly cationic,
which range from simple small-size molecular fragments or complexes to large-size cluster …

Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive
peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer's …

Theoretical and experimental studies have been conducted to elucidate the mechanism of
the formal nucleophilic boryl substitution of aryl and alkyl bromides with silylborane in the …

For the last 15 years, kinetic target-guided syntheses, including in situ click chemistry, have
been used as alternative methods to find ligands to therapeutically relevant proteins. In this …

The interaction of the alkali metal cations, Li+, Na+, and K+, with the amino acid proline (Pro)
and its four-and six-membered ring analogues, azetidine-2-carboxylic acid (Aze) and …

The interactions of alkali metal cations (M+= Li+, Na+, K+, Rb+) with the amino acid cysteine
(Cys) are examined in detail. Experimentally, bond energies are determined using threshold …

A theoretical model, based in density functional theory with the B3LYP functional and the
DZVP basis set from Salahub, has been applied for the calculation of the binding affinity and …

The binding of K+ to glycine is examined in detail by studying the interaction of the
potassium cation with glycine and ligands that contain the functional components of glycine …