The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a
replication-competent form of the virus accumulates and persists with more stable kinetic …

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

The thymus represents the major site of the production and generation of T cells expressing
αβ-type T-cell antigen receptors. Age-related involution may affect the ability of the thymus to …

To understand the high variability of the asymptomatic interval between primary human
immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied …

Summary Background Hepatitis C virus (HCV) infection is highly prevalent among HIV-1-
infected individuals, but its contribution to the morbidity and mortality of coinfected patients …

The size and composition of the CD4+ T-cell population is regulated by balanced
proliferation of progenitor cells and death of mature progeny. After infection with the human …

Clinical observations indicate that elderly people are prone to severe, often lethal infectious
diseases induced by novel pathogens. Since the ability to mount primary immune responses …

The discovery of effective therapy for human immunodeficiency virus (HIV) infection has
improved the outlook for patients with the acquired immunodeficiency syndrome (AIDS)(75 …

Upon transmission to a new host, HIV targets CCR5+ CD4+ effector memory T cells,
resulting in acute, massive depletion of these cells from mucosal effector sites. This …