Background The growing understanding of the importance of a healthy microbiome is
challenging traditional thinking that resulted in the general acceptance of the Germ Theory …

The brain-intestinal axis concept describes the communication between the intestinal
microbiota as an ecosystem of a number of dynamic microorganisms and the brain. The …

Bacterial pneumonia is a major cause of mechanical ventilation in intensive care units. We
hypothesized that the presence of particular microbiota in endotracheal tube aspirates …

The gut is hypothesised to play an important role in the development and progression of
sepsis. It is however unknown whether the gut microbiome and the gut barrier function is …

Acute lung injury (ALI) is a clinical syndrome characterized by a diffuse lung inflammation
that commonly evolves into acute respiratory distress syndrome and respiratory failure. The …

Background Patients with sepsis-induced acute respiratory distress syndrome (ARDS) have
a high mortality rate. Early, targeted antibiotic therapy is crucial for patient survival. The …

Sepsis is triggered by infection-induced immune alteration and may be theoretically
improved by pharmacological and extracorporeal immune modulating therapies …

Background The emergence of multi-drug resistant pathogens is an urgent health-related
problem, and the appropriate use of antibiotics is imperative. It is often difficult to identify the …

The role of the gut microbiome in critical illness is being actively investigated, but the optimal
sampling methods for sequencing studies of gut microbiota remain unknown. Stool samples …

Sepsis, a systemic inflammation as a response to a bacterial infection, is a huge unmet
medical need. Data accumulated over the last decade suggest that the nutritional status of …