Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance
to conventional therapies, including temozolomide, the most widely used chemotherapeutic …

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …

Background Tumor recurrence, the chief reason for poor prognosis of glioma, is largely
attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT) …

The progression of glioblastomas is associated with a variety of neurological impairments,
such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of …

Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1), indoleamine 2, 3-dioxygenase 2 (IDO2),
and tryptophan 2, 3-dioxygenase (TDO) initiate the first step of the kynurenine pathway (KP) …

Simple Summary In this review, the thorny issue of glioblastoma models is addressed, with a
focus on 3D in vitro models. In the first part of the manuscript, glioblastoma features and …

Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …

Diffuse gliomas are the most frequent brain tumours, representing 75% of all primary
malignant brain tumours in adults. Because of their locally aggressive behaviour and the fact …

Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal
phenotypes with adverse prognosis. Here, we perform multi-omic profiling of 60 …