EAG (ether-à-go-go or KCNH) are a subfamily of the voltage-gated potassium (Kv) channels.
Like for all potassium channels, opening of EAG channels drives the membrane potential …

Voltage-dependent potassium channels (Kv channels) are crucial regulators of cell
excitability that participate in a range of physiological and pathophysiological processes …

It has been suggested that deficient protein trafficking to the cell membrane is the dominant
mechanism associated with type 2 Long QT syndrome (LQT2) caused by Kv11. 1 potassium …

The KCNH voltage-dependent potassium channels (ether-à-go-go, EAG; EAG-related gene,
ERG; EAG-like channels, ELK) are important regulators of cellular excitability,, and have key …

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …

The human ether-à-go-go–related gene (hERG) encodes a K+ channel crucial for
repolarization of the cardiac action potential. EAG-related gene (ERG) channels contain a C …

Slow deactivation is a critical property of voltage-gated K+ channels encoded by the human
Ether-à-go-go-Related Gene 1 (hERG). hERG1 channel deactivation is modulated by …

Human Ether-à-go-go (hERG) channels contribute to cardiac repolarization, and inherited
variants or drug block are associated with long QT syndrome type 2 (LQTS2) and …

The intracellular domains of many ion channels are important for fine-tuning their gating
kinetics. In Kv11. 1 channels, the slow kinetics of channel deactivation, which are critical for …

The hERG (human-ether-à-go-go-related gene) channel underlies the rapid delayed rectifier
current, Ikr, in the heart, which is essential for normal cardiac electrical activity and rhythm …