[HTML][HTML] Palmitic acid: physiological role, metabolism and nutritional implications

G Carta, E Murru, S Banni, C Manca - Frontiers in physiology, 2017 - frontiersin.org
Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

[HTML][HTML] Bioactive lipids and chronic inflammation: managing the fire within

V Chiurchiù, A Leuti, M Maccarrone - Frontiers in immunology, 2018 - frontiersin.org
Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

FA Iannotti, V Di Marzo, S Petrosino - Progress in lipid research, 2016 - Elsevier
The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

S Petrosino, V Di Marzo - British journal of pharmacology, 2017 - Wiley Online Library
Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

[HTML][HTML] Chronic pain in the elderly: mechanisms and distinctive features

A Tinnirello, S Mazzoleni, C Santi - Biomolecules, 2021 - mdpi.com
Background: Chronic pain is a major issue affecting more than 50% of the older population
and up to 80% of nursing homes residents. Research on pain in the elderly focuses mainly …

[HTML][HTML] Palmitoylethanolamide: a natural compound for health management

P Clayton, M Hill, N Bogoda, S Subah… - International journal of …, 2021 - mdpi.com
All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: an update

H Ren, R Han, X Chen, X Liu, J Wan… - Journal of Cerebral …, 2020 - journals.sagepub.com
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

[HTML][HTML] Mast cells, neuroinflammation and pain in fibromyalgia syndrome

TC Theoharides, I Tsilioni, M Bawazeer - Frontiers in Cellular …, 2019 - frontiersin.org
Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain,
accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive …

[HTML][HTML] Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential

DJ Vesga-Jiménez, C Martin, GE Barreto… - International journal of …, 2022 - mdpi.com
One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …