This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Background The poor physical health of people with mental illness is a multifaceted,
transdiagnostic, and global problem. People with mental illness have an increased risk of …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

Suicide and self-harm are major health and societal issues worldwide, but the greatest
burden of both behaviours occurs in low-income and middle-income countries. Although …

Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally
believed that their longterm use is harmful for patients' physical wellbeing. However, there …

BackgroundTreatment-resistant schizophrenia (TRS) is associated with high levels of
functional impairment, healthcare usage and societal costs. Cross-sectional studies may …

A recent increase in the literature regarding the evidence base for clozapine has made it
increasingly difficult for clinicians to judge “best evidence” for clozapine use. As such, we …

People with schizophrenia die 1520 years prematurely. Understanding mortality risk and
aggravating/attenuating factors is essential to reduce this gap. We conducted a systematic …

With the ongoing coronavirus disease 2019 (COVID-19) pandemic, psychiatrists find
themselves in the clinical situation of being asked by patients, family members and patient …