Purpose: In RE-MIND2 (NCT04697160), patient-level outcomes from the L-MIND study
(NCT02399085) of tafasitamab plus lenalidomide were retrospectively compared with …

Disagreement remains on what the target estimand should be for population-adjusted
indirect treatment comparisons. This debate is of central importance for policy-makers and …

Background When studying the association between treatment and a clinical outcome, a
parametric multivariable model of the conditional outcome expectation is often used to …

Clinical trials with a hybrid control arm (a control arm constructed from a combination of
randomized patients and real-world data on patients receiving usual care in standard …

Objectives This study aimed to demonstrate enhanced survival extrapolation methods using
electronic health record-derived real-world data (RWD). Methods The study population …

Health technology assessment systems base their decision-making on health-economic
evaluations. These require accurate relative treatment effect estimates for specific patient …

Background To extend the discussion on the use of real-world evidence (RWE) in conveying
the clinical value of treatment beyond trial data, the primary objective of this study was to …

Outcomes in electronic health records (EHR)-derived cohorts can be compared to similarly
treated clinical trial cohorts to estimate the efficacy-effectiveness gap, the discrepancy in …

Electronic health records (EHR) contain a wealth of information that can potentially be used
for research. EHR is particularly valuable for accelerating comparative effectiveness …

Healthcare facilities routinely collect medical and patient data and electronically record them
when patients use their facilities. Measurements of blood pressure, prescribed medications …