Increased generation of reactive oxygen species (ROS) and the subsequent DNA damage
and excessive activation of poly (ADP-ribose) polymerase-1 (PARP-1) have been implicated …

Cadaveric renal transplants suffer frequently from delayed graft function, which is associated
with increased risk for long-term graft survival loss. One-third of kidney grafts that are stored …

Ischemic acute renal failure is characterized by damages to the proximal straight tubule in
the outer medulla. Lesions include loss of polarity, shedding into the tubule lumen, and …

Cisplatin is one of the most effective chemotherapeutics, but its usefulness is limited by its
toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of these …

Ischemic postconditioning is a phenomenon that intermittent interruptions of blood flow in
the early phase of reperfusion can protect organ from ischemia/reperfusion (I/R) injury. In the …

Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or
transplantation, is a major cause of acute renal failure. Previous studies showed that ozone …

Nanoparticles have emerged in the medical field as a technology well suited for the
diagnosis and treatment of various disease states. They have been heralded as efficacious …

The general description of kinins refers to these peptides as molecules involved in vascular
tone regulation and inflammation. Nevertheless, in the last years a series of evidences has …

Ischemia is the most frequent cause of acute kidney injury (AKI), which is characterized by
apoptosis of renal tubular cell. A common result of ischemia in AKI is dysfunction of …

Ischemia reperfusion injury (IRI) causes tissue and organ injury, in part, through alterations
in tissue blood flow and the production of reactive oxygen species. The cell surface receptor …