The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression
that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all …

Patterns of DNA cytosine methylation are subject to mitotic inheritance in both plants and
vertebrates. Plants use 5-methylcytosine glycosylases and the base excision repair pathway …

Background—The epigenome refers to marks on the genome, including DNA methylation
and histone modifications, that regulate the expression of underlying genes. A consistent …

Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations
in epigenetic marks, including DNA methylation, are potentially heritable, they can also be …

Transcriptional coregulators control the activity of many transcription factors and are thought
to have wide-ranging effects on gene expression patterns. We show here that muscle …

Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

In the mouse liver, circadian transcriptional rhythms are necessary for metabolic
homeostasis. Whether dynamic epigenomic modifications are associated with transcript …