The rate of calcium cycling and calcium transient amplitude are critical determinants for the
efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

Abstract Adenosine 3′, 5′-cyclic monophosphate (cAMP) acts as a second messenger
that is involved in the regulation of a plethora of processes. The activation of cAMP signaling …

Familial dilated cardiomyopathy is a prevalent cause of heart failure that results from the
mutation of genes encoding proteins of diverse function. Despite modern therapy, dilated …