Conformational dynamics of intrinsically disordered proteins regulate biomolecular condensate chemistry
Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical
reactions are executed inside of biomolecular condensates formed by ultradynamic …
reactions are executed inside of biomolecular condensates formed by ultradynamic …
Structure, dynamics, assembly, and evolution of protein complexes
JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …
biological processes. In recent decades, many thousands of homomeric and heteromeric …
[HTML][HTML] flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
G Hu, A Katuwawala, K Wang, Z Wu… - Nature …, 2021 - nature.com
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …
computational predictions from primary structures, complements secondary and tertiary …
[HTML][HTML] Dynamic foldamer chemistry
BAF Le Bailly, J Clayden - Chemical Communications, 2016 - pubs.rsc.org
Foldamers can be made more than pieces of static, conformationally uniform molecular
architecture by designing into their structure the conformational dynamism characteristic of …
architecture by designing into their structure the conformational dynamism characteristic of …
Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy
Y Sakiyama, A Mazur, LE Kapinos, RYH Lim - Nature nanotechnology, 2016 - nature.com
Nuclear pore complexes (NPCs) are biological nanomachines that mediate the bidirectional
traffic of macromolecules between the cytoplasm and nucleus in eukaryotic cells. This …
traffic of macromolecules between the cytoplasm and nucleus in eukaryotic cells. This …
Molecular recognition features (MoRFs) in three domains of life
Intrinsically disordered proteins and protein regions offer numerous advantages in the
context of protein–protein interactions when compared to the structured proteins and …
context of protein–protein interactions when compared to the structured proteins and …
High-throughput prediction of RNA, DNA and protein binding regions mediated by intrinsic disorder
Intrinsically disordered proteins and regions (IDPs and IDRs) lack stable 3D structure under
physiological conditions in-vitro, are common in eukaryotes, and facilitate interactions with …
physiological conditions in-vitro, are common in eukaryotes, and facilitate interactions with …
Protein intrinsic disorder and structure-function continuum
VN Uversky - Progress in molecular biology and translational …, 2019 - Elsevier
The functional proteome of a given organism noticeably exceeds its corresponding genome
due to various events at the DNA (genetic variations), mRNA (alternative splicing, alternative …
due to various events at the DNA (genetic variations), mRNA (alternative splicing, alternative …
Binding without folding–the biomolecular function of disordered polyelectrolyte complexes
Highlights•Highly charged intrinsically disordered proteins can form high-affinity complexes
without gain of structure or site-specific interactions.•Such highly disordered polyelectrolyte …
without gain of structure or site-specific interactions.•Such highly disordered polyelectrolyte …