Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …

Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers
with a high incidence rate worldwide. The current treatment including surgery …

In the current medical era, the single target inhibition paradigm of drug discovery has given
way to the multi-target design concept. As the most intricate pathological process …

The target of the study is to modify the efficiency of Molnupiravir-drug (MOL) for COVID-19
therapy via the rearrangement of the building engineering of MOL-drug by loading it with self …

A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and
their chemical structures were confirmed by spectral data (infrared, 1 H & 13 C NMR and …

Ulcerative colitis (UC) is a persistent inflammatory bowel disease (IBD) that is regarded as a
risk factor for cognitive impairment. Donepezil (DON), a centrally acting acetylcholinesterase …

The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their
in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities …

Abstract Synthesis, characterization (1 H NMR, 13 C NMR, FT-IR, elemental analysis), and
DFT studies of the 3-(4-chlorophenyl)-5-(4-ethoxyphenyl)-4, 5-dihydropyrazole-1 …

Multiple inhibitions of CA, COX-2 and 5-LOX enzymes has been recognised as a useful
strategy for the development of anti-inflammatory drugs that can avoid the disadvantages of …

Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …