The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current …

Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious
worldwide health concern and a significant healthcare burden. As the majority of …

Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the
pathophysiology of cognition. While the brain RAS has been studied before in the context of …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

The renin-angiotensin system (RAS) is one of the oldest hormone systems in vertebrate
phylogeny. RAS was initially related to regulation of blood pressure and sodium and water …

The sympathetic nervous system plays a critical role in the pathogenesis of hypertension.
The central nervous system (CNS) organizes the sympathetic outflow and various inputs …

Nakagawa and Sigmund Regulation of the Brain RAS 11 processing proteases including
tonin and cathepsin G with a broad spectrum of substrate affinities. 27 Ang-(1–12), a peptide …

While the role of the renin–angiotensin system (RAS) in peripheral circulation is well
characterized, we still lack an in-depth understanding of its role within the brain. This …