Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Cellular cytotoxicity, the ability to kill other cells, is an important effector mechanism of the
immune system to combat viral infections and cancer. Cytotoxic T cells and natural killer …

Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the
engagement of RCD pathways does not inevitably result in cell death. Instead, RCD …

It is now well established that tumours undergo changes in cellular metabolism 1. As this
can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose …

Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic
cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the …

The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells
adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic …

The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …

Non-alcoholic fatty liver disease (NAFLD) shows an increasing prevalence and is
associated with the development of liver fibrosis and cirrhosis as the major risk factors of …