Background. Alzheimer's disease (AD) is a progressive neurodegenerative disorder
affecting many individuals worldwide with no effective treatment to date. AD is characterized …

Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …

It was recently discovered that brain cells release extracellular vesicles (EV) which can pass
from brain into blood. These findings raise the possibility that brain-derived EV's present in …

Synaptic vesicle glycoprotein 2A (SV2A) is expressed ubiquitously in neurons of the central
nervous system, and is the binding target of the anti-epileptic drug levetiracetam. Because of …

The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Alzheimer's Disease (AD) remains one of the most challenging health-related issues for our
society. It is becoming increasingly prevalent, especially in developed countries, due to the …

Structural disruption and alterations of synapses are associated with many brain disorders
including Alzheimer's disease, epilepsy, depression, and schizophrenia. We have …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
neuron losses in memory-associated brain structures that rob patients of their dignity and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
senile plaques (SPs), which are caused by amyloid beta (Aβ) deposition and neurofibrillary …

We and others have shown that [18F]-Flortaucipir, the most validated tau PET tracer thus far,
binds with strong affinity to tau aggregates in Alzheimer's (AD) but has relatively low affinity …