Antidepressant prescribing has increased year on year since the introduction of the selective
serotonin reuptake inhibitors (SSRIs) in the 1980s. More than 10% of adults in England are …

Use of antidepressants has recently increased, mainly caused by the increase of long-term
users. Although evidence-based indications for long-term use are lacking, it is assumed that …

Background Antidepressants are commonly prescribed. There are clear national guidelines
in relation to treatment sequencing. This study examines trends and variation in …

Background Antidepressant prescribing continues to increase, with 5-16% of adults
receiving antidepressants annually. Total prescribing growth is due in part to increased long …

Background Both the 2004 NICE depression guidelines and 2006 general practice Quality
Outcomes Framework (QOF) encouraged improved targeting of antidepressant treatment for …

Objectives Antidepressant prescribing almost doubled in the Netherlands between 1996
and 2012, which could be accounted for by longer continuation after the first prescription …

Shared decision-making that considers treatment history, comorbidities, costs, and risk of
adverse effects should be used when choosing an antidepressant. When discontinuing an …

Objectives We aimed to develop a digital intervention to support antidepressant
discontinuation in UK primary care that is scalable, accessible, safe and feasible. In this …

Background Around one in ten adults take antidepressants for depression in England, and
their long-term use is increasing. Some need them to prevent relapse, but 30–50% could …

Importance There is significant concern regarding increasing long-term antidepressant
treatment for depression beyond an evidence-based duration. Objective To determine …