The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

Neuroinflammation has either beneficial or detrimental effects, depending on risk factors and
neuron–glia interactions in neurological disorders. However, studying neuroinflammation …

PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate
the biology of this central nervous system (CNS)-resident myeloid population, but the …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) engraftment
is a promising therapy for acute ischemic stroke (AIS). However, the harsh ischemic …

Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the
central nervous system (CNS) and regulates neuronal survival and myelination in the adult …

Central nervous system (CNS) diseases threaten the health of people all over the world.
However, due to the structural and functional particularities of the brain and spinal cord …

Microglia are the only resident innate immune cells derived from the mesoderm in the nerve
tissue. They play a role in the development and maturation of the central nervous system …

Abstracts Ethnopharmacological relevance Saikosaponins B2 (SSB2) is one of the main
active components isolated from Radix Bupleuri (Bupleurum chinense DC.), a herb widely …

As part of the central nervous system (CNS), retinal ganglion cells (RGCs) and their axons
are the only neurons in the retina that transmit visual signals from the eye to the brain via the …