Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

Stroke, the third leading cause of death and disability worldwide, is classified into ischemic
or hemorrhagic, in which approximately 85% of strokes are ischemic. Ischemic stroke occurs …

Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the
central nervous system (CNS) and regulates neuronal survival and myelination in the adult …

Microglia, the resident macrophages of the central nervous system (CNS), play a critical role
in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating …

Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

Neuroinflammation refers to a highly complicated reaction of the central nervous system
(CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a …

Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While
therapies exist to slow MS progression, no treatment currently exists for remyelination …

Abstract Background Gemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α,
a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower …

The tight junction of endothelial cells in the central nervous system (CNS) has an ideal
characteristic, acting as a biological barrier that can securely regulate the movement of …

Background Recently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed
important cellular and functional features of Alzheimer's disease (AD), a prevalent …