Background: Sulforaphane (SFN) is an isothiocyanate of vegetable origin with potent
antioxidant and immunomodulatory properties. The characterization of its pleiotropic activity …

Substantial evidence suggests a role for immunotherapy in treating Alzheimer's disease
(AD). While the precise pathophysiology of AD is incompletely understood, clinical trials of …

Background Development of clinically effective neuroprotective agents for stroke therapy is
still a challenging task. Microglia play a critical role in brain injury and recovery after …

Retinitis pigmentosa (RP) is an outer retinal degenerative disease that can lead to
photoreceptor cell death and profound vision loss. Although effective regulation of …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, but
therapeutic strategies to slow down AD pathology and symptoms have not yet been …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …

Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with
high morbidity and mortality, for which no brain-targeted therapies exist at present. The …

Background Sepsis-associated encephalopathy (SAE) is characterized by symptoms of
delirium including hallucinations, impaired concentration, agitation, or coma and is …

Traumatic brain injury (TBI) results from mechanical force to the brain and leads to a series
of biochemical responses that further damage neurons and supporting cells. Clinically, most …

In the central nervous system, microglia are responsible for removing infectious agents,
damaged/dead cells, and amyloid plaques by phagocytosis. Other cell types, such as …