How far are we from reliable metabolomics-based biomarkers? The often-overlooked importance of addressing inter-individual variability factors

Á González-Domínguez… - Biochimica et Biophysica …, 2023 - Elsevier
Metabolomics has proven great potential to unravel the molecular basis of diseases.
However, most attempts aimed at identifying reliable metabolomics-based biomarkers for …

[HTML][HTML] Childhood obesity, metabolic syndrome, and oxidative stress: microRNAs go on stage

Á González-Domínguez, T Belmonte… - Reviews in Endocrine …, 2023 - Springer
The incidence of childhood obesity and metabolic syndrome has grown notably in the last
years, becoming major public health burdens in developed countries. Nowadays, oxidative …

Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity

Á González‐Domínguez, J Domínguez‐Riscart… - …, 2023 - Wiley Online Library
Although puberty is known to influence obesity progression, the molecular mechanisms
underlying the role of sexual maturation in obesity‐related complications remains largely …

Association Between Blood Selenium Levels and Stroke: A Study Based on the NHANES (2011-2018)

K Zhao, Y Zhang, W Sui - Biological Trace Element Research, 2024 - Springer
At present, the association between circulating selenium and stroke is still in dispute. Thus,
this study aimed to ascertain the association with a larger sample size than the previous …

[HTML][HTML] Exploring the association between circulating trace elements, metabolic risk factors, and the adherence to a Mediterranean diet among children and …

Á González-Domínguez, J Domínguez-Riscart… - Frontiers in Public …, 2023 - frontiersin.org
Diet is one of the most important modifiable lifestyle factors for preventing and treating
obesity. In this respect, the Mediterranean diet (MD) has proven to be a rich source of a …

[HTML][HTML] Anti-obesity and anti-inflammatory synergistic effects of green tea catechins and citrus β-cryptoxanthin ingestion in obese mice

K Nakadate, K Kawakami, N Yamazaki - International Journal of …, 2023 - mdpi.com
Chronic obesity causes various diseases, leading to an urgent need for its treatment and
prevention. Using monosodium-glutamate-induced obesity mice, the present study …

[HTML][HTML] Parental obesity predisposes to exacerbated metabolic and inflammatory disturbances in childhood obesity within the framework of an altered profile of trace …

Á González-Domínguez, L Jurado-Sumariva… - Nutrition & …, 2024 - nature.com
Background Family history of obesity is known to increase the odds of developing childhood
obesity in the offspring, but its influence in underlying molecular complications remains …

QComics: Recommendations and Guidelines for Robust, Easily Implementable and Reportable Quality Control of Metabolomics Data

Á González-Domínguez, N Estanyol-Torres… - Analytical …, 2024 - ACS Publications
The implementation of quality control strategies is crucial to ensure the reproducibility,
accuracy, and meaningfulness of metabolomics data. However, this pivotal step is often …

[HTML][HTML] Vanadium, cobalt, zinc, and rubidium are associated with markers of inflammation and oxidative stress in a Greek population with obesity

C Amerikanou, SA Kleftaki, S Karavoltsos… - Frontiers in …, 2023 - frontiersin.org
Introduction The prevalence of obesity is rising globally, with negative effects on the
socioeconomic system. As a result of its drivers which include low-grade chronic …

Association between childhood obesity, trace elements, and heavy metals: Recent discoveries and future perspectives

Á González‐Domínguez, L Jurado‐Sumariva… - Obesity …, 2024 - Wiley Online Library
Trace elements and heavy metals play pivotal roles in health status by regulating a myriad of
vital biological functions. Abnormal metal homeostasis has been linked to a constellation of …