The human skeleton has remarkable regenerative properties, being one of the few
structures in the body that can heal by recreating its normal cellular composition, orientation …

Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

Bone tissue renewal can be outlined as a complicated mechanism centered on the
interaction between osteogenic and angiogenic events capable of leading to bone formation …

Traumatic injuries can lead to large bone defects under extreme conditions, which usually
take a long recovery period, while the prognosis is poor. Endogenous electric field, as one …

Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients,
hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is …

Critical size bone defects are frequently caused by accidental trauma, oncologic surgery,
and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of …

Bone regeneration is a complex process requiring highly orchestrated interactions between
different cells and signals to form new mineralized tissue. Blood vessels serve as a structural …

Background The regeneration of periodontal bone defect remains a vital clinical challenge.
To date, numerous biomaterials have been applied in this field. However, the immune …