[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
[PDF][PDF] Myeloid cells in the central nervous system
The central nervous system (CNS) and its meningeal coverings accommodate a diverse
myeloid compartment that includes parenchymal microglia and perivascular macrophages …
myeloid compartment that includes parenchymal microglia and perivascular macrophages …
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Immune dysfunction is commonly associated with several neurological and mental
disorders. Although the mechanisms by which peripheral immunity may influence neuronal …
disorders. Although the mechanisms by which peripheral immunity may influence neuronal …
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex
E Gerrits, LAA Giannini, N Brouwer, S Melhem… - Nature …, 2022 - nature.com
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia,
affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the …
affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the …
[PDF][PDF] C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
D Lall, I Lorenzini, TA Mota, S Bell, TE Mahan… - Neuron, 2021 - cell.com
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis
(ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression …
(ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression …
Neuroinflammation in frontotemporal dementia
Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …
disorders with different pathological signatures, genetic variability and complex disease …
The neuropathology and cerebrovascular mechanisms of dementia
L Raz, J Knoefel, K Bhaskar - Journal of Cerebral Blood Flow …, 2016 - journals.sagepub.com
The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …
Because of the heterogeneity of clinical presentation and complexity of disease …
Progranulin, lysosomal regulation and neurodegenerative disease
The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …
[PDF][PDF] Human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice
OM Peters, GT Cabrera, H Tran, TF Gendron… - Neuron, 2015 - cell.com
A non-coding hexanucleotide repeat expansion in the C9ORF72 gene is the most common
mutation associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal …
mutation associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal …
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis
Heterozygous mutations in the GRN gene lead to progranulin (PGRN) haploinsufficiency
and cause frontotemporal dementia (FTD), a neurodegenerative syndrome of older adults …
and cause frontotemporal dementia (FTD), a neurodegenerative syndrome of older adults …