Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …

This monograph presents a general mathematical theory for biological growth. It provides
both a conceptual and a technical foundation for the understanding and analysis of …

Introduction Clinical remission as a multicomponent treatment goal in severe asthma is
being explored in clinical practice. This post hoc analysis used data from the REDES study …

Rationale: Cross-sectional analysis of mucus plugs in computed tomography (CT) lung
scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug …

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow
obstruction, airway remodelling (measurable structural change) and inflammation. The …

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
limitation caused by emphysema and/or airway narrowing. Computed tomography has been …

Angiogenesis and microvascular remodeling are known features of chronic inflammatory
diseases such as asthma and chronic bronchitis, but the mechanisms and consequences of …

Background To prospectively apply an automated, quantitative three-dimensional approach
to imaging and airway analysis to assess airway remodeling in asthma patients. Methods …

Background High-resolution CT (HRCT) scanning is part of the management of severe
asthma, but its application varies between centers. We sought to describe the HRCT scan …