In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Medicinal plants have been used from the beginning of human civilization, which is mostly
evident from the ancient script and traditional herbal medicine recipe. Despite the historically …

Somatic stem cells have been identified in multiple adult tissues. Whether self-renewal
occurs symmetrically or asymmetrically is key to understanding long-term stem cell …

Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …

Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues
by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do …

The stem cell transcription factor Sox2 is highly expressed in many cancers where it is
thought to mark cancer stem cells (CSCs). In osteosarcomas, the most common bone …

We propose an evolutionary perspective to classify and characterize the diverse systems of
adaptive immunity that have been discovered across all major domains of life. We put …

Cancer stem cells (CSCs) exhibit intrinsic therapy/stress resistance, which often cause
cancer recurrence after therapy. In this study, we investigated the potential relationship …

A genetic continuity of living organisms relies on the germline which is a specialized cell
lineage producing gametes. Essential in the germline functioning is the protection of genetic …