In vitro maturation (IVM) has been applied in numerous different contexts and strategies in
humans and animals, but in both cases it represents a challenge still far from being …

Abstract Development of the mammalian oocyte requires physical contact with the
surrounding granulosa cells of the follicle, which provide it with essential nutrients and …

Polycystic ovary syndrome (PCOS) is a complex heterogeneous disorder with reproductive
and metabolic consequences whose aetiology is still elusive. To understand the cellular …

Abstract Ethnopharmacological relevant Yangjing Zhongyu decoction (YJZYD) is a recipe
from a Chinese classic medical work and has been empirically used in female infertility for …

Pre-incubation of the cumulus-oocyte complex (COCs) may lead to better function of
cumulus cells (CCs) and higher oocyte quality by changing the transcriptomic profile of CCs …

In vitro maturation (IVM) is not a routine assisted reproductive technology (ART) for oocytes
collected from early antral (EA) follicles, a large source of potentially available gametes …

Advanced maternal age is a major cause of infertility, miscarriage, and congenital
abnormalities. This is principally caused by a decrease in oocyte quality and developmental …

To sustain energy-demanding developmental processes, oocytes must accumulate
adequate stores of metabolic substrates and mitochondrial numbers prior to the initiation of …

Introduction Developmental competence of oocytes matured in vitro is limited due to a lack
of complete understanding of metabolism and metabolic gene expression during oocyte …

Introduction Ovarian low response to follicle-stimulating hormone (FSH) causes infertility
featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian …