Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

The development of germ cells relies on contact and communication with neighboring
somatic cells that provide metabolic support and regulatory signals. In females, contact is …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

Mitochondrial function and glucose metabolism play important roles in bidirectional
signaling between granulosa cells (GCs) and oocytes. However, the factors associated with …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

The mitochondria, present in almost all eukaryotic cells, produce energy but also contribute
to many other essential cellular functions. One of the unique characteristics of the …

Ovarian reserve (OR) and fertility are critical in women's healthcare. Clinical methods for
encoding OR and fertility rely on the combination of tests, which cannot serve as a multi …

BACKGROUND Fertility loss during female ageing is associated with increasing basal FSH
and decreasing anti-Müllerian hormone (AMH) concentrations, together with compromised …

Chemo‐phototherapy has emerged as a promising approach to complement traditional
cancer treatment and enhance therapeutic effects. However, it still faces the challenges of …

The ovarian reserve is defined as the quantity of oocytes stored in the ovary or the number of
oocytes that can be recruited. Ovarian reserve can be affected by many factors, including …