Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …

Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress.
We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the …

Alkaloids include a family of naturally occurring chemical compounds containing mostly
basic nitrogen atoms. Piperine is an alkaloid present in black pepper (Piper nigrum), one of …

Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in
industrialized countries. The discovery of food components that can ameliorate NAFLD is …

Metformin is a first-line drug for treating type 2 diabetes. Although metformin is known to
phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the glucose-lowering …

Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the
nuclear receptor family of transcription factors and plays essential roles in the transcriptional …

Background Oltipraz is a synthetic dithiolethione with an antisteatotic effect by inhibiting the
activity of liver X receptor alpha (LXR‐α). Recent studies demonstrated the disruptive role of …

Comprehensive studies support the notion that the peroxisome proliferator‐activated
receptors,(PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis …

Liver X receptor-α (LXRα), a member of the nuclear receptor superfamily of ligand-activated
transcription factors, regulates de novo fatty acid synthesis that leads to stimulate hepatic …

Abstract Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl
pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting …