Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Background Exosomes are progressively known as significant mediators of cell-to-cell
communication. They convey active biomolecules to target cells and have vital functions in …

Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

ABSTRACT KRAS is the most frequently mutated oncogene in human neoplasia. Despite a
large investment to understand the effects of KRAS mutation in cancer cells, the direct effects …

Cancer is a complex disease that is associated with genetic aberrations and subsequent
cellular and noncellular host responses. Tumors harbor diverse cell types that engage in a …

Background & Aims Autophagy plays a crucial role in hepatic homeostasis and its
deregulation has been associated with chronic liver disease. However, the effect of …

The endolysosome system plays central roles in both autophagic degradation and secretory
pathways, including the release of extracellular vesicles and particles (EVPs). Although …

Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally
divided into exosomes and microvesicles on basis of their origination from the endosomal …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid
accumulation and subsequent inflammatory and profibrotic response. Therapeutic efforts at …