Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …

Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are
reviewed. The construction of oligosaccharides of defined connectivity hinges on such …

Deoxy-sugars often play a critical role in modulating the potency of many bioactive natural
products. Accordingly, there has been sustained interest in methods for their synthesis over …

Non-covalent interactions (NCIs) are a vital component of biological bond-forming events,
and have found important applications in multiple branches of chemistry. In recent years, the …

Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …

A critical review of the state-of-the-art evidence in support of the mechanisms of
glycosylation reactions is provided. Factors affecting the stability of putative oxocarbenium …

The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Photoredox catalysis has recently emerged as a powerful synthetic platform for accessing
complex chemical structures through non-traditional bond disconnection strategies that …

Enzymes achieve high substrate and product selectivities by orientating and activating the
substrate (s) appropriately inside a confined and finely optimized binding pocket. Although …

Conspectus Glycans are complex compounds consisting of sugars linked glycosidically,
existing either as pure polysaccharides or as part of glycoconjugates. They are prevalent in …