Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …

Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …

This study aimed to investigate the chemical composition as well as the antibacterial,
antiparasitic, and cytotoxic potentialities of the Brazilian Chrysopogon zizanioides root …

Cathepsin B represents a group of lysosomal-encapsulated cellular cysteine proteases,
whose upregulation is the critical risk factor for cancer progression and in the regulation of …

A series of 28 compounds, 3-nitro-1 H-1, 2, 4-triazole, were synthesized by click-chemistry
with diverse substitution patterns using medicinal chemistry approaches, such as …

Since the beginning of the XXI century, Leishmaniasis has been integrated into the World
Health Organization's list of the 20 neglected tropical diseases, being considered a public …

Leishmaniasis is a group of infectious diseases caused by protozoan parasites that belong
to the genus Leishmania. Currently, there is no human vaccine, and the available treatments …

The treatment against leishmaniasis presents problems, mainly due to their toxicity of the
drugs, high cost and/or by the emergence of parasite resistant strains. In this context, new …

Triazole, which can exist in two isomeric forms: 1, 2, 3-and 1, 2, 4-triazole, is considered to
be a privileged scaffold with recognized biological and pharmaceutical potential …

The triazolobenzodiazepine as a cyclic imine was employed in a variety of Joullié–Ugi
reactions, and three new families of unique triazolobenzodiazepine connected to …