Dysregulated cell division, which leads to aberrant cell proliferation, is one of the key
hallmarks of cancer. Therefore, therapeutic targets that block cell division would be effective …

Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Covering: 2007. Previous review: Nat. Prod. Rep., 2008, 25, 35This review covers the
literature published in 2007 for marine natural products, with 948 citations (627 for the …

Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased
understanding of disease pathobiology and genomics has led to clinical investigation of …

The phosphorylation of proteins on serine, threonine, and tyrosine residues by the 518
protein kinases encoded in the human genome constitutes one of the major mechanisms …

Unlike other CDKs, CDK9 does not regulate the cell cycle but promotes RNA synthesis in
genetic programmes for cell growth, differentiation and viral pathogenesis. It is becoming …

Cyclin-dependent kinase 9 (CDK9), which regulates transcriptional elongation, is an
attractive therapeutic target for many cancers, especially for cancers driven by transcriptional …

Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …

Cancer denotes a pathological manifestation that is characterized by hyperproliferation of
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …