MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling
Rett syndrome (RTT) is an X-linked, neurodevelopmental disorder caused primarily by
mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes a …
mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes a …
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …
etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have …
Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations
Protein-coding de novo mutations (DNMs) are significant risk factors in many
neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs …
neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs …
Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis
The similarities and differences between nervous systems of various species result from
developmental constraints and specific adaptations,,–. Comparative analyses of the …
developmental constraints and specific adaptations,,–. Comparative analyses of the …
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
[PDF][PDF] De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies
Emerging evidence indicates that epileptic encephalopathies are genetically highly
heterogeneous, underscoring the need for large cohorts of well-characterized individuals to …
heterogeneous, underscoring the need for large cohorts of well-characterized individuals to …
[HTML][HTML] Cortical organoids model early brain development disrupted by 16p11. 2 copy number variants in autism
Reciprocal deletion and duplication of the 16p11. 2 region is the most common copy number
variation (CNV) associated with autism spectrum disorders. We generated cortical organoids …
variation (CNV) associated with autism spectrum disorders. We generated cortical organoids …
De novo mutations in synaptic transmission genes including DNM1 cause epileptic
EuroEPINOMICS-RES Consortium - American journal of human …, 2014 - escholarship.org
Emerging evidence indicates that epileptic encephalopathies are genetically highly
heterogeneous, underscoring the need for large cohorts of well-characterized individuals to …
heterogeneous, underscoring the need for large cohorts of well-characterized individuals to …
Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder
AG Cardno, MJ Owen - Schizophrenia bulletin, 2014 - academic.oup.com
There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …