Despite considerable genetic heterogeneity underlying neurodevelopmental diseases, there
is compelling evidence that many disease genes will map to a much smaller number of …

Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

Although schizophrenia (SZ) is defined by waking phenomena, abnormal sleep is a
common feature. In particular, there is accumulating evidence of a sleep spindle deficit …

We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …

Although de novo missense mutations have been predicted to account for more cases of
autism than gene-truncating mutations, most research has focused on the latter. We …

In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …

The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …

Currently, many studies on neuropsychiatric disorders have utilized massive trio-based
whole-exome sequencing (WES) and whole-genome sequencing (WGS) to identify …

Single-cell transcriptomics provides an opportunity to characterize cell-type-specific
transcriptional networks, intercellular signaling pathways and cellular diversity with …

We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …