Carbohydrate-based macromolecular biomaterials

L Su, Y Feng, K Wei, X Xu, R Liu, G Chen - Chemical Reviews, 2021 - ACS Publications
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Synthetic carbohydrate-based vaccines: challenges and opportunities

R Mettu, CY Chen, CY Wu - Journal of Biomedical Science, 2020 - Springer
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been
extremely successful in preventing bacterial infections. The glycan antigens for the …

Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

Design and synthesis of glycomimetics: Recent advances

A Tamburrini, C Colombo… - Medicinal research …, 2020 - Wiley Online Library
In the past few decades, our understanding of glycan information‐encoding power has
notably increased, thus leading to a significant growth also in the design and synthesis of …

[HTML][HTML] Gold nanoparticle-based platforms for vaccine development

RM Ferrando, L Lay, L Polito - Drug Discovery Today: Technologies, 2020 - Elsevier
Since their discovery, therapeutic or prophylactic vaccines represent a promising option to
prevent or cure infections and other pathologies, such as cancer or autoimmune disorders …

Nucleotide sugars in chemistry and biology

S Mikkola - Molecules, 2020 - mdpi.com
Nucleotide sugars have essential roles in every living creature. They are the building blocks
of the biosynthesis of carbohydrates and their conjugates. They are involved in processes …

Glycans in drug discovery

P Valverde, A Ardá, NC Reichardt… - …, 2019 - pubs.rsc.org
Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

Recent advances on smart glycoconjugate vaccines in infections and cancer

M Anderluh, F Berti, A Bzducha‐Wróbel… - The FEBS …, 2022 - Wiley Online Library
Vaccination is one of the greatest achievements in biomedical research preventing death
and morbidity in many infectious diseases through the induction of pathogen‐specific …

Carbohydrate conjugates in vaccine developments

S Lang, X Huang - Frontiers in Chemistry, 2020 - frontiersin.org
Vaccines are powerful tools that can activate the immune system for protection against
various diseases. As carbohydrates can play important roles in immune recognition, they …

Total Syntheses of Conjugation-Ready Trisaccharide Repeating Units of Pseudomonas aeruginosa O11 and Staphylococcus aureus Type 5 Capsular …

A Behera, D Rai, SS Kulkarni - Journal of the American Chemical …, 2019 - ACS Publications
Pseudomonas aeruginosa belongs to the group of three “critical priority” multi-drug-resistant
pathogens listed by WHO and is responsible for severe and often deadly infections such as …