It is now well established that reactive oxygen species (ROS), reactive nitrogen species
(RNS), and a basal level of oxidative stress are essential for cell survival. It is also well …

Background and Aims Evidence shows that antioxidant supplements may increase mortality.
Our aims were to assess whether different doses of beta-carotene, vitamin A, and vitamin E …

In C. elegans, the skn‐1 gene encodes a transcription factor that resembles mammalian Nrf2
and activates a detoxification response. skn‐1 promotes resistance to oxidative stress (Oxr) …

Coenzyme Q (CoQ) is a unique electron carrier in the mitochondrial respiratory chain, which
is synthesized on-site by a nuclear encoded multiprotein complex. CoQ receives electrons …

Toxicity caused by the exposure to human-made chemicals and environmental conditions
has become a major health concern because they may significantly increase the formation …

Peroxidation of lipids, particularly polyunsaturated fatty acid residues (PUFA) of
phospholipids and cholesterol esters, is a process of marked implications: it shortens the …

Oxidative stress is defined by an imbalance between increased levels of reactive oxygen
species (ROS) and a low activity of antioxidant mechanisms. An increased oxidative stress …

Cell cycle arrest is not yet senescence. When the cell cycle is arrested, an inappropriate
growth-promotion converts an arrest into senescence (geroconversion). By inhibiting the …

Background & aim Inflammation and oxidative stress are the most probable mechanistic link
between obesity and its co-diseases with cancer among them. The aim of this study was to …

More people die from cardiovascular diseases (CVD) than from any other cause.
Cardiovascular complications are thought to arise from enhanced levels of free radicals …