Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies

Y Shen, X Cao, M Lu, H Gu, M Li, DA Posner - Smart Medicine, 2022 - Wiley Online Library
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as
damages done to our central nervous system (CNS). The patients' physical and mental …

[HTML][HTML] Therapeutic potential of niche-specific mesenchymal stromal cells for spinal cord injury repair

SL Lindsay, SC Barnett - Cells, 2021 - mdpi.com
The use of mesenchymal stem/stromal cells (MSCs) for transplant-mediated repair
represents an important and promising therapeutic strategy after spinal cord injury (SCI) …

[HTML][HTML] The potential of gene therapies for spinal cord injury repair: a systematic review and meta-analysis of pre-clinical studies

CJ Cunningham, M Viskontas, K Janowicz… - Neural Regeneration …, 2023 - journals.lww.com
Currently, there is no cure for traumatic spinal cord injury but one therapeutic approach
showing promise is gene therapy. In this systematic review and meta-analysis, we aim to …

[HTML][HTML] Improving motor neuron-like cell differentiation of hEnSCs by the combination of epothilone B loaded PCL microspheres in optimized 3D collagen hydrogel

N Mahmoodi, J Ai, Z Hassannejad… - Scientific Reports, 2021 - nature.com
Spinal cord regeneration is limited due to various obstacles and complex pathophysiological
events after injury. Combination therapy is one approach that recently garnered attention for …

[HTML][HTML] Blood-spinal cord barrier disruption in degenerative cervical myelopathy

HW Kim, H Yong, GKH Shea - Fluids and Barriers of the CNS, 2023 - Springer
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord
dysfunction in the aging population. Significant neurological deficits may result from a …

[HTML][HTML] Stem cell neurodevelopmental solutions for restorative treatments of the human trunk and spine

ZT Olmsted, JL Paluh - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
The ability to reliably repair spinal cord injuries (SCI) will be one of the greatest human
achievements realized in regenerative medicine. Until recently, the cellular path to this goal …

Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury

TK McGuire, M Stasiewicz, I Woods… - Advanced …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a devastating traumatic injury often causing permanent loss of
function. The challenge of treating SCI stems from the development of a complex …

Current insights into the management of spinal cord injury

N Srikandarajah, MA Alvi, MG Fehlings - Journal of Orthopaedics, 2023 - Elsevier
Background Traumatic spinal cord injury (SCI) is a serious disorder that results in severe
impairment of neurological function as well as disability, ultimately reducing a patient's …

[HTML][HTML] Neural stem cells overexpressing arginine decarboxylase improve functional recovery from spinal cord injury in a mouse model

YM Park, JH Kim, JE Lee - International journal of molecular sciences, 2022 - mdpi.com
Current therapeutic strategies for spinal cord injury (SCI) cannot fully facilitate neural
regeneration or improve function. Arginine decarboxylase (ADC) synthesizes agmatine, an …

[HTML][HTML] Reverse adverse immune microenvironments by biomaterials enhance the repair of spinal cord injury

H Wang, Y Xia, B Li, Y Li, C Fu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a severe and traumatic disorder that ultimately results in the loss
of motor, sensory, and autonomic nervous function. After SCI, local immune inflammatory …