Current treatments after spinal cord injury: Cell engineering, tissue engineering, and combined therapies
Both traumatic and non‐traumatic spinal cord injuries (SCIs) can be categorized as
damages done to our central nervous system (CNS). The patients' physical and mental …
damages done to our central nervous system (CNS). The patients' physical and mental …
[HTML][HTML] Therapeutic potential of niche-specific mesenchymal stromal cells for spinal cord injury repair
SL Lindsay, SC Barnett - Cells, 2021 - mdpi.com
The use of mesenchymal stem/stromal cells (MSCs) for transplant-mediated repair
represents an important and promising therapeutic strategy after spinal cord injury (SCI) …
represents an important and promising therapeutic strategy after spinal cord injury (SCI) …
[HTML][HTML] The potential of gene therapies for spinal cord injury repair: a systematic review and meta-analysis of pre-clinical studies
CJ Cunningham, M Viskontas, K Janowicz… - Neural Regeneration …, 2023 - journals.lww.com
Currently, there is no cure for traumatic spinal cord injury but one therapeutic approach
showing promise is gene therapy. In this systematic review and meta-analysis, we aim to …
showing promise is gene therapy. In this systematic review and meta-analysis, we aim to …
[HTML][HTML] Improving motor neuron-like cell differentiation of hEnSCs by the combination of epothilone B loaded PCL microspheres in optimized 3D collagen hydrogel
Spinal cord regeneration is limited due to various obstacles and complex pathophysiological
events after injury. Combination therapy is one approach that recently garnered attention for …
events after injury. Combination therapy is one approach that recently garnered attention for …
[HTML][HTML] Blood-spinal cord barrier disruption in degenerative cervical myelopathy
HW Kim, H Yong, GKH Shea - Fluids and Barriers of the CNS, 2023 - Springer
Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord
dysfunction in the aging population. Significant neurological deficits may result from a …
dysfunction in the aging population. Significant neurological deficits may result from a …
[HTML][HTML] Stem cell neurodevelopmental solutions for restorative treatments of the human trunk and spine
ZT Olmsted, JL Paluh - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
The ability to reliably repair spinal cord injuries (SCI) will be one of the greatest human
achievements realized in regenerative medicine. Until recently, the cellular path to this goal …
achievements realized in regenerative medicine. Until recently, the cellular path to this goal …
Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury
TK McGuire, M Stasiewicz, I Woods… - Advanced …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a devastating traumatic injury often causing permanent loss of
function. The challenge of treating SCI stems from the development of a complex …
function. The challenge of treating SCI stems from the development of a complex …
Current insights into the management of spinal cord injury
N Srikandarajah, MA Alvi, MG Fehlings - Journal of Orthopaedics, 2023 - Elsevier
Background Traumatic spinal cord injury (SCI) is a serious disorder that results in severe
impairment of neurological function as well as disability, ultimately reducing a patient's …
impairment of neurological function as well as disability, ultimately reducing a patient's …
[HTML][HTML] Neural stem cells overexpressing arginine decarboxylase improve functional recovery from spinal cord injury in a mouse model
YM Park, JH Kim, JE Lee - International journal of molecular sciences, 2022 - mdpi.com
Current therapeutic strategies for spinal cord injury (SCI) cannot fully facilitate neural
regeneration or improve function. Arginine decarboxylase (ADC) synthesizes agmatine, an …
regeneration or improve function. Arginine decarboxylase (ADC) synthesizes agmatine, an …
[HTML][HTML] Reverse adverse immune microenvironments by biomaterials enhance the repair of spinal cord injury
H Wang, Y Xia, B Li, Y Li, C Fu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a severe and traumatic disorder that ultimately results in the loss
of motor, sensory, and autonomic nervous function. After SCI, local immune inflammatory …
of motor, sensory, and autonomic nervous function. After SCI, local immune inflammatory …