The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is
controversial, putatively involving diffusible factors and/or electrotonic spread of …

It is becoming increasingly evident that electrical signaling via gap junctions plays a central
role in the physiological control of vascular tone via two related mechanisms (1) the …

Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

There is now strong evidence that an endothelial mechanism, other than nitric oxide or
prostacyclin, exists for dilating arteries and arterioles. This third pathway has been named …

Endothelium-dependent smooth muscle hyperpolarization (EDH) increasingly predominates
over endothelium-derived nitric oxide (NO) as a participant in vasodilation as vessel size …

We have investigated the role of cAMP in NO-and prostanoid-independent relaxations that
are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF). Under …

Gap junction channels provide the basis for intercellular communication and play an
important physiological role in the cardiovascular system for maintenance of the normal …