Cardiac fibroblasts are emerging as key components of normal cardiac function, as well as
the response to stressors and injury. These most numerous cells of the heart interact with …

Aldosterone in the development and progression of renal injury. Background The renin-
angiotensin-aldosterone system (RAAS) contributes to hypertension and nephropathy. Until …

We investigated the effects on the heart of hypertension due to the excess of aldosterone
and suppression of the renin-angiotensin system caused by primary aldosteronism with M …

Background Since hyperaldosteronism has been experimentally related to myocardial
interstitial fibrosis, we investigated the effects of hypertension and excess aldosterone due to …

Angiotensin II is a potent arterial vasoconstrictor and induces hypertension. Angiotensin II
also exerts a trophic effect on cardiomyocytes in vitro. The goals of the present study were to …

Cardiovascular magnetic resonance imaging (CMR) has become the gold standard not only
for cardiac volume and function quantification, but for a key unique strength: non-invasive …

Alterations in activities of one family of proteases, the matrix metalloproteinases (MMPs),
have been implicated in primary and metastatic tumor growth, angiogenesis, and …

The rat aorta, whose three wall layers can be separated by microdissection offers the rare
possibility of comparing physiological characteristics of in vivo tissular cell components and …

BACKGROUND During senescence, the plasma angiotensin II concentration is decreased,
but the regulation of intracardiac angiotensin II synthesis has never been investigated. The …

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAMl), a substrate of the
insulin receptor tyrosine kinase, regulates insulin action by promoting insulin clearance …