Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Gut microbiome and neuroinflammation in hypertension

EM Richards, J Li, BR Stevens, CJ Pepine… - Circulation …, 2022 - Am Heart Assoc
Hypertension is a worldwide problem with major impacts on health including morbidity and
mortality, as well as consumption of health care resources. Nearly 50% of American adults …

Gut microbiota and acute central nervous system injury: a new target for therapeutic intervention

B Yuan, X Lu, Q Wu - Frontiers in immunology, 2021 - frontiersin.org
Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI),
and spinal cord injury (SCI), are the common causes of death or lifelong disabilities …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Glial-neuronal interactions in pathogenesis and treatment of spinal cord injury

N Lukacova, A Kisucka, K Kiss Bimbova… - International Journal of …, 2021 - mdpi.com
Traumatic spinal cord injury (SCI) elicits an acute inflammatory response which comprises
numerous cell populations. It is driven by the immediate response of macrophages and …

Advances in molecular therapies for targeting pathophysiology in spinal cord injury

HN Kim, MR McCrea, S Li - Expert opinion on therapeutic targets, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Role of NLRP3 Inflammasome in post-spinal-cord-injury anxiety and depression: molecular mechanisms and therapeutic implications

T Mokhtari, K Uludag - ACS Chemical Neuroscience, 2023 - ACS Publications
The majority of research on the long-term effects of spinal cord injury (SCI) has primarily
focused on neuropathic pain (NP), psychological issues, and sensorimotor impairments …

“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction

H Zheng, C Zhang, J Zhang, L Duan - Protein & Cell, 2023 - academic.oup.com
Abnormal brain–gut interaction is considered the core pathological mechanism behind the
disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an …

[HTML][HTML] Neuromotor decline is associated with gut dysbiosis following surgical decompression for Degenerative Cervical Myelopathy

PM Vidal, S Brockie, C Farkas, J Hong, C Zhou… - Neurobiology of …, 2024 - Elsevier
Degenerative cervical myelopathy (DCM) describes a spectrum of disorders that cause
progressive and chronic cervical spinal cord compression. The clinical presentation can be …

Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach

S Bhatt, K Anitha, DK Chellappan, D Mukherjee… - Metabolic Brain …, 2024 - Springer
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Approximately,
around 2% to 3% percent of the general population experience symptoms of OCD over the …