Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …

Studies in recent years have uncovered the crucial function of neuroimmune interactions in
maintaining tissue homeostasis and protection. Immune and neuronal cells are often …

Nociceptive pain is a hallmark of many chronic inflammatory conditions including
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …

Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …

Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …

Recent advances have contributed to a mechanistic understanding of neuroimmune
interactions in the intestine and revealed an essential role of this cross talk for gut …

One of the first signs of viral infection is body-wide aches and pain. Although this type of pain
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …

Background Lung nociceptor neurons amplify immune cell activity and mucus metaplasia in
response to an inhaled allergen challenge in sensitized mice. Objective We sought to …

Although acute itch has a protective role by removing irritants to avoid further damage,
chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a …

The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the
cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether …