Collagen type I is the main organic constituent of the bone extracellular matrix and has been
used for decades as scaffolding material in bone tissue engineering approaches when …

Bone fracture healing is a multistep and overlapping process of inflammation, angiogenesis
and osteogenesis. It is initiated by inflammation, causing the release of various cytokines …

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and have
diverse functions during development and organogenesis. BMPs play a major role in …

BMPs are members of the transforming growth factor-β (TGF-β) superfamily and have been
extensively studied due to their excellent osteoinductive ability and multiple functions …

Molecular signals in the form of growth factors are the main modulators of cell behavior.
However, the use of growth factors in tissue engineering has several drawbacks, including …

Mesenchymal stem/progenitor cells (MSCs) are key players in regenerative medicine,
relying principally on their differentiation/regeneration potential, immunomodulatory …

There remains a great need to develop therapeutic agents to treat critical size defects and
non-union fractures and one of the potential agents is recombinant human fibroblast growth …

Although bone morphogenetic protein-6 (BMP-6) has been identified as a tumor suppressor
associated with breast cancer differentiation and metastasis, the potential roles of BMP-6 in …

Abstract Bone morphogenetic protein‐2 (BMP‐2) is widely used in orthopedic surgery and
bone tissue engineering because of its strong osteogenic activity. However, BMP‐2 …

Interest in discovering new methods of employing natural growth factor preparations to
promote bone fracture healing is becoming increasingly popular in the field of regenerative …